AGINGSCIENCES™ – Anti-Aging Firewalls™

[...] causal association remains tenuous. Nonetheless, this ambiguity does not imply that ROS or oxidative stress do not play an important role in the aging process. Rather, the steady-state amounts of [...]

[...] major flow in the “telomere clock concept” occurred when it was discovered that oxidative stress accelerated telomere shortening and that telomere shortening could occur even in cells that [...]

[...] in males in Western industrialized countries, is characterized by increased intracellular oxidative stress. Chronic oxidative stress and its associated pathological conditions including inflammation [...]

[...] in cases of vasospasm. The 2012 publication Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhagereports:  “Background: [...]

[...] members of the Sirtuin family, SIRT6 and SIRT7. Major SIRT1 Functions #1: Preventing cellular senescence  –SIRT1 prevents cell cycle arrest via six mechanisms.  We first list these mechanisms and [...]

[...] other interesting things are present in the list above – the genes involved with cellular senescence can be silenced (p16INK4a, Rb, etc.).  This may explain why cellular senescence does [...]

[...] this “long distance suppression” by the SNP. Image source The 9p21.3 locus and Cellular Senescence In addition to being associated with atherosclerotic disease, the p16INK4a is a tumor [...]

[...] of the mutant protein in primary fibroblasts is associated with telomere-based cellular senescence, multinucleated cells and the activation of the DNA damage response genes ATM, Chk2 and p53. [...]

[...] By James P Watson with editorial assistance and a few comments by Vince Giuliano This is Part 2 of 3 in the series The View from the Telomere end of the Chromsome.& [...]

[...] By Vince Giuliano with important contributions by James P Watson Glucosamine is one of the most popular dietary [...]

[...] By Vince Giuliano with inputs from James P Watson, Victor, and Melody Winnig Many of our most basic [...]

[...] By Vince Giuliano and Melody Winnig Frequent readers of this blog are familiar with the fundamental importance [...]

[...] blog is a summary review of trends with links to many (but by far not all) of the some 460 blog entries we have generated. TRENDS Jim Watson and I have published blogs of “Top-12 things I have [...]

[...] but almost none raising the topic of epigenetics.  Have I been kidding myself when I wrote two blog entries a couple of years ago asserting that epigenetic evolution is the key source of human [...]

[...] to treating it (February, 2010).  Other important parts of the story will be in forthcoming blog entries, including disussion of tau tangles and possible new preventative and therapeutic approaches. [...]

[...] and activities that are reflecting and driving the changes in narratives.  In each of the blog entries we look at aging from individual and from social perspectives.  We also surface some of [...]

[...] -cancer agent. There is an increasing number of research studies focused on elucidating the molecular mechanisms of GA-induced anti-cancer effects, and several critical signaling pathways have been [...]

[...] are also being developed. In this review, we aim to survey relevant research, the molecular mechanisms of signalling, including upstream activation and downstream effectors, and the role of [...]

[...] cell stress responses.  Food scientists have largely been oblivious to the molecular mechanisms of such stress preconditioning on foods.  And they understand the net results [...]

[...] found in chocolate that are so good for us. References: Publications related to the molecular mechanisms of the above and other modes of plant polyphenol production include: The grapevine [...]