Regenerative Cellular Therapy

[...] treating brain diseases by engineering an experimental molecular therapy that crosses the blood-brain barrier to reverse neurological lysosomal storage disease in mice. Posted online in PNAS Early [...]

[...] . (A peptide is a very short protein sequence.) Second, blood levels of a specific group of immune cells that inappropriately home in on and destroy a protein found only on beta cells appear to have [...]

[...] to determine which were the most specific and immunogenic (i.e., raised the strongest immune response in test animals), and therefore were best suited for use as vaccines or therapeutics. The [...]

[...] delivered initially promising results, suggesting that it may selectively counter the errant immune response that causes the disease. Several important findings of the multicenter, randomized, double- [...]

[...] worldwide cases of diabetes, is caused by an abnormal immune response that kills the insulin-producing beta cells in the pancreas. Until now, nobody has found a way to address the root cause of this [...]

[...] a small set of immune cells believed to be a fundamental driver of the attack on insulin-producing beta cells that causes type-1 diabetes. Different cells make different proteins, and they [...]

[...] a complicated and time-consuming process, and it can take many years just to identify the therapeutic protein, determine its gene sequence, and validate a process to make the molecules using [...]

[...] -derived transgene expression (GFP) in chondrocytes 6 months post-injection. AAVIL-1ra therapeutic protein levels were 200–800 ng/ml of synovial fluid over 23 and 186 days, respectively. No [...]

[...] Researchers Target HER1 Receptor for Peptide Cancer Vaccine, Therapeutic Agents Small proteins called peptides that consist of 10 to 50 amino acids [...]

[...] of protein production over extended time supporting further clinical investigation using scAAV gene therapy for OA. Introduction Osteoarthritis (OA) is a progressive and debilitating joint disease [...]

[...] interleukin-1 receptor antagonist (IL-1ra) gene transfer in an equine model based on IL-1ra protein therapy which inhibits inflammation through blocking IL-1. Using the self-complementary adeno- [...]